Anticoagulants

Item Number: 10968   correct answer: 2  category: Anticoagulants
1.   A patient diagnosed with a deep venous thrombosis is begun on a heparin
infusion of 1000 U/HR after a 5000 U Bolus.  The earliest you can draw blood
for an aPTT reflecting steady-state heparin is:
1. 4 hours
2. 7.5 hours
3. 12 hours
4. 24 hours
5. None of the above

Item Number: 10973   correct answer: 2  category: Anticoagulants
2.   The direct-acting plasminogen activator is:
1. streptokinase
2. urokinase
3. epsilon-aminocaproic acid
4. anistreplase
5. heparin

Item Number: 10980   correct answer: 4  category: Anticoagulants
3.   The antithrombotic drug which inhibits cyclooxygenase enzymes is:
1. prednisone
2. dipyridamole
3. tranexamic acid
4. aspirin
5. ticlopidine

Item Number: 10983   correct answer: 3  category: Anticoagulants
4.   Correct statements about the action of warfarin include:
     A.   warfarin is structurally similar to vitamin K and competitively
          inhibits liver synthesis of clotting factors
     B.   warfarin inhibits vitamin K epoxide reductase
     C.   the onset of warfarin action may be prolonged due to the long
          half-life of factor VII
     D.   factors II, VII, IX, and X are not activated (carboxylated) when
          warfarin is administered in therapeutic doses
1. A,B,C
2. A,C
3. B,D
4. D only
5. All of the above


Item Number: 10988   correct answer: 3  category: Anticoagulants
5.   Drugs which interact with warfarin to increase its anticoagulant effect
include:
     A.  ranitidine
     B.  trimethoprim/sulfamethoxazole
     C.  rifampin
     D.  nonsteroidal anti-inflammatory drugs
1. A,B,C
2. A,C
3. B,D
4. D only
5. All of the above

Item Number: 11018   correct answer: 1  category: Anticoagulants
6.   The mechanism of action of mini-dose heparin is correctly described by:
     A.   factor X is more sensitive to heparin than are other serine
          protease factors
     B.   mini-dose heparin is useful prophylactically rather than during
          active clot formation
     C.   by inhibiting factor X activation, a relative block of the
          clotting cascade develops, with less thrombin formed
     D.   the major action is to directly inhibit factor II, which is very
          sensitive to heparin
1. A,B,C
2. A,C
3. B,D
4. D only
5. All of the above

Item Number: 11041   correct answer: 2  category: Anticoagulants
7.   The correct statement about fibrinolytic agents is:
1.   streptokinase acts directly to activate plasminogen
2.   urokinase acts directly to activate plasminogen
3.   tissue-type specific plasminogen activator is more fibrin specific than
     streptokinase
4.   side effects of t-PA include skin rash, allergic reactions, and
     development of antibodies
5.   have been shown to increase mortality when given in the setting of an
     acute myocardial infarction