Pulmonary

Item Number: 10835   correct answer: 1  category: Pulmonary
1.   Proposed cellular mechanisms of theophylline's action include:
     A. translocation of intracellular calcium
     B. those mediated by increasing accumulation of intracellular cyclic AMP
     C. those mediated by blockade of receptors for adenosine
     D. those mediated by xanthine oxidase inhibition
1. A,B,C
2. A,C
3. B,D
4. D only
5. All of the above

Item Number: 10841   correct answer: 2  category: Pulmonary
2.   Drugs that may decrease theophylline clearance include:
     A.  cimetidine
     B.  ranitidine
     C.  ciprofloxacin
     D.  phenytoin
1. A,B,C
2. A,C
3. B,D
4. D only
5. All of the above

Item Number: 10854   correct answer: 5  category: Pulmonary
3.   Theophylline clearance may be reduced by:
1. phenobarbital
2. warfarin
3. tobacco smoking
4. phenytoin
5. ciprofloxacin

Item Number: 10856   correct answer: 5  category: Pulmonary
4.   Factors which are important to consider in selecting a maintenance dose of
theophylline in a patient include all of the following EXCEPT:
1. smoking history
2. concomitant medication administration
3. presence of congestive heart failure or cor pulmonale
4. presence of hepatic failure
5. presence of renal insufficiency

Item Number: 10879   correct answer: 5  category: Pulmonary
5.   Manifestations of theophylline toxicity may include all of the following
EXCEPT:
1. tremors
2. seizures
3. tachyarrhythmias
4. vomiting
5. hyperkalemia

Item Number: 10886   correct answer: 2  category: Pulmonary
6.   In the case of an oral overdose of theophylline, clearance may be enhanced by:
1. induction of emesis
2. oral pulse dose charcoal
3. administration of cimetidine
4. lavage of nasogastric contents
5. forced diuresis

Item Number: 10897   correct answer: 4  category: Pulmonary
7.   Regarding its actions, cromolyn is best described as:
1. bronchodilator
2. anticholinergic
3. beta agonist
4. inhibitor of mast cell degranulation
5. glucocorticoid

Item Number: 10915   correct answer: 4  category: Pulmonary
8.   Beta-2 selective adrenergic agonists include all EXCEPT:
1. terbutaline
2. albuterol
3. metaproterenol
4. isoproterenol
5. pirbuterol

Item Number: 10917   correct answer: 5  category: Pulmonary
9.   Adverse effects of beta-2 adrenergic bronchodilators include all of the
following EXCEPT:
1. nervousness
2. headache
3. tachycardia
4. tremulousness
5. lethargy
                                                                  
Item Number: 10923   correct answer: 4  category: Pulmonary
10.   Which of the following work through cholinergic receptor antagonism?
1. isoetharine
2. cromolyn
3. ephedrine
4. ipratropium
5. salmeterol

Item Number: 8694   correct answer: 1  category: Pulmonary
11.   Which of the following pharmacologic agents antagonize adenosine?
1. theophylline
2. glucocorticoids 
3. cromolyn sodium
4. propranolol
5. terbutaline

Item Number: 8322   correct answer: 2  category: Pulmonary
12.   Theophylline, ethacrynic acid, and furosemide:
1. interfere with active renal tubular reabsorption of sodium
2. increase urine volume
3. are not effective in the treatment of congestive heart failure
4. decrease excretion of sodium in the urine
5. may precipitate in renal tubules and cause acute angiospastic necrosis

Item Number: 4329   correct answer: 4  category: Pulmonary
13.   An 81-year-old female with arteriosclerotic heart disease and pulmonary
emphysema was found to have significant bronchospasm. Her physician prescribed
theophylline 400 mg every 12 hours. All of the following toxicities may be
observed EXCEPT:
1. cardiac arrhythmias
2. nausea and vomiting
3. agitation
4. sodium and water retention
5. tremulousness

Item Number: 13988  correct answer: 5  category: Pulmonary
14.   When comparing the relative adrenergic effects of the following drugs, the one
which would have the least  2 (bronchodilatation) effect at normal doses is:
1. terbutaline
2. epinephrine
3. isoproterenol
4. isoetharine
5. norepinephrine