Insulin/OHA


Item Number: 11057 correct answer: 5 category: Insulin OHA, #1.
STATEMENTS WHICH CORRECTLY DESCRIBE THE PHARMACOKINETICS OF INSULIN
INCLUDE:

1. THE VOLUME OF DISTRIBUTION OF INSULIN IS EXTRACELLULAR
FLUID
2. INSULIN UNDERGOES FIRST-PASS HEPATIC METABOLISM
3. INSULIN IS FILTERED BY THE RENAL GLOMERULI AND REABSORBED
BY THE TUBULES, WHICH ALSO DEGRADE IT
4. THE HALF-LIFE OF IV INSULIN IS LESS THAN 9 MINUTES
5. ALL OF THE ABOVE

GOODMAN'S PHARMACOL BASIS THERAP, 1985, P. 1495
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Item Number: 11061 correct answer: 5 category: Insulin OHA, #2.
Gastrointestinal hormones which are responsible for greater insulin activity aften an oral glucose load than an intravenous glucose load include:

1. Gip
2. Gastrin
3. Pancreozymin-cholecystokinin
4. Secretin
5. All of the above

GoodmanÕs Pharmacol Basis Therap, 1990, pp. 1466-7
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Item Number: 11062 correct answer: 3 category: Insulin OHA, #3.
The metabolic actions of insulin may be described as:

1. Increased rate of transport of glucose into the brain
2. Increased conversion of protein to glucose
3. Inhibition of hormone-sensitive lipase
4. Enhanced glycogenolysis
5. Enhanced glycosuria

Goodman's Pharmacol Basis Therap, 1990, pp. 1471-4
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Item Number: 11066 correct answer: 3 category: Insulin OHA, #4.
WHICH OF THE FOLLOWING ROWS IN THE CHART ARE CORRECT?
INSULIN ONSET(HR) PEAK DURATION
A. ULTRALENTE 1-2 4-6 18-24
B. REGULAR 1/2-1 2-4 5-7
C. NPH 1-1 1/2 6-10 15-20
D. LENTE 1-2 1/2 6-14 24+

1. A, B, and C
2. A and C
3. B and D
4. D only
5. ALL OF THE ABOVE

GOODMAN'S PHARMACOL BASIS THERAP, 1985, P. 1506
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Item Number: 11072 correct answer: 4 category: Insulin OHA, #5.
POTENTIAL SIDE EFFECTS OF THERAPY WITH CHLORPROPAMIDE INCLUDE ALL
OF THE FOLLOWING EXCEPT:

1. SIADH (SYNDROME OF INAPPROPRIATE ADH SECRETION)
2. ''ANTABUSE'' REACTION
3. SKIN RASH
4. LACTIC ACIDOSIS
5. HYPOGLYCEMIA

GOODMAN'S PHARMACOL BASIS THERAP, 1985, P. 1506
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Item Number: 11073 correct answer: 2 category: Insulin OHA, #6.
STATEMENTS WHICH DESCRIBE THE STRUCTURE-ACTIVITY RELATIONSHIPS OF ORAL
HYPOGLYCEMIC DRUGS INCLUDE:
A. BOTH FIRST AND SECOND GENERATION AGENTS ARE SULPHONYLUREAS
B. Larger R SUBSTITUENTS AND INCREASED DISTANCE BETWEEN N ATOMS
ON THE SULPHONYLUREA STRUCTURE RENDER FIRST GENERATION MORE
POTENT THAN 2ND GENERATION COMPOUNDS
C. SECOND GENERATION AGENTS ARE LESS POLAR AND TEND TO BIND LESS
READILY TO ALBUMIN THAN 1ST GENERATION AGENTS
D. DUE TO THE SIMILARITY OF SULPHONYLUREAS TO SULFONAMIDES, IT IS
NOT SURPRISING THAT SULPHONYLUREAS ARE BACTERIOSTATIC

1. A, B, and C
2. A and C
3. B and D
4. D only
5. ALL OF THE ABOVE

CLIN PHARM 1984; 3:481-2
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Item Number: 11084 correct answer: 5 category: Insulin OHA, #7.
STATEMENTS WHICH EXPLAIN THE MECHANISM OF ACTION OF ORAL
SULPHONYLUREA AGENTS INCLUDE ALL OF THE FOLLOWING EXCEPT:

1. DECREASED HEPATIC GLUCOSE PRODUCTION
2. INCREASED TISSUE SENSITIVITY TO INSULIN
3. INCREASED INSULIN BINDING TO THE INSULIN RECEPTOR
4. CORRECTION OF POST-RECEPTOR DEFECTS WHICH CONTRIBUTE
TO INSULIN
5. REGENERATE BETA CELLS OF THE PANCREASE

CLIN PHARM 1984; 3:474-5
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Item Number: 5146 correct answer: 3 category: Insulin OHA, #8.
HYPONATREMIA HAS BEEN ASSOCIATED WITH CARBAMAZEPINE AND CERTAIN ORAL
HYPOGLYCEMIC AGENTS. ORAL HYPOGLYCEMIC AGENTS WHICH HAVE BEEN
ASSOCIATED WITH SIADH INCLUDE:
A. GLIPIZIDE
B. TOLBUTAMIDE
C. TOLAZAMIDE
D. CHLORPROPAMIDE

1. A, B, and C
2. A and C
3. B and D
4. D only
5. ALL OF THE ABOVE

Goodman's Pharmacol Basis Therap, 1990, p. 1486
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