Antituberculars

Item Number: 714   correct answer: 1  category: Antituberculars
1.   The route by which isoniazid is usually administered is:
1. oral
2. intramuscular injection of solution
3. intramuscular injection of suspension
4. subcutaneous injection of solution
5. intravenous



Item Number: 673   correct answer: 3  category: Antituberculars
2.   Rifampin is used mainly in the treatment of:
1. cholera
2. typhoid fever
3. tuberculosis
4. rickettsial diseases
5. pseudomonas infections

Item Number: 665   correct answer: 2  category: Antituberculars
3.   Impaired vision is an adverse effect of:
1. carbenicillin
2. ethambutol
3. rifampin
4. colistin
5. cycloserine

Item Number: 1595   correct answer: 3  category: Antituberculars
4.   Various drugs may induce vitamin deficient states as an undesirable side
effect.  Vitam B6 (pyridoxine) deficiency may be related to taking:
1. estrogen-containing oral contraceptives
2. colchicine
3. isoniazid
4. All of the above
5. 1,3

Item Number: 4943   correct answer: 2  category: Antituberculars
5.   Most adults who are at high risk of developing pulmonary tuberculosis should
be treated with:
1. isoniazid 100 mg/day for 6 months
2. isoniazid 300 mg/day for 12 months
3. ethambutol 400 mg/day for 12 months
4. rifampin 600 mg/day for 24 months
5. No treatment is necessary

Item Number: 4944   correct answer: 2  category: Antituberculars
6.   An antitubercular agent which is associated with the development of ocular
toxicity is:
1. rifampin
2. ethambutol
3. isoniazid
4. streptomycin
5. para-aminosalicylic acid


Item Number: 4945   correct answer: 4  category: Antituberculars
7.   Which of the following antitubercular agents is associated with the
development of ototoxicity?
1. rifampin
2. ethambutol
3. isoniazid
4. streptomycin
5. para-aminosalicylic acid

Item Number: 4972   correct answer: 5  category: Antituberculars
8.   Which of the following antibiotics is most closely associated with the
development of ocular toxicity?
1. kanamycin
2. penicillin G
3. tetracycline
4. isoniazid
5. ethambutol

Item Number: 4973   correct answer: 4  category: Antituberculars
9.   Which of the following antibiotics is most closely associated with the
development of hepatitis?
1. kanamycin
2. penicillin G
3. tetracycline
4. isoniazid
5. ethambutol

Item Number: 4975   correct answer: 1  category: Antituberculars
10.   Which of the following antibiotics is most closely associated with the
development of renal and ototoxicity?
1. kanamycin
2. penicillin G
3. tetracycline
4. isoniazid
5. ethambutol

Item Number: 5147   correct answer: 3  category: Antituberculars
11.   Which of the following agents used in the treatment of pulmonary tuberculosis
has the side effect of loss of perception of the color green?
1. isoniazid
2. rifampin
3. ethambutol
4. streptomycin
5. para-amino salicylic acid


Item Number: 5148   correct answer: 1  category: Antituberculars
12.   Which of the following agents used in the treatment of pulmonary tuberculosis
has a toxicity of producing a lupus-like syndrome?
1. isoniazid
2. rifampin
3. ethambutol
4. streptomycin
5. para-amino salicylic acid

Item Number: 5509   correct answer: 3  category: Antituberculars
13.   Isoniazid-induced liver damage:
1.   occurs primarily in patients under 30 years of age
2.   occurs with increased frequency in patients receiving concomitant
     ethambutol therapy
3.   is probably due to the formation of a toxic hydrazine metabolite that
     binds to liver protein
4.   is frequently associated with allergic manifestations such as
     eosinophilia, fever, and rash
5.   All of the above

Item Number: 9758   correct answer: 4  category: Antituberculars
14.   Tubercle bacilli exist in tuberculous patients in three pools extracellular,
intracellular, and necrotic caseum. The only drug which is bactericidal for
all three is:
1. isoniazid
2. ethambutol
3. pyrazinamide
4. rifampin
5. streptomycin

Item Number: 9759   correct answer: 2  category: Antituberculars
15.   All of the following are considered primary drugs in the current therapeutic
approaches to the treatment of tuberculosis EXCEPT:
1. streptomycin
2. para-aminosalicylic acid
3. isoniazid
4. rifampin
5. ethambutol

Item Number: 9760   correct answer: 5  category: Antituberculars
16.   Which of the following antitubercular drugs has hyperuricemia as one of its
well-documented untoward effects?
1. streptomycin
2. isoniazid
3. cycloserine
4. rifampin
5. pyrazinamide


Item Number: 9761   correct answer: 1  category: Antituberculars
17.   Which of the following is a bactericidal antitubercular drug that has an
inhibitory action on cell wall synthesis?
1. isoniazid
2. rifampin
3. ethambutol
4. streptomycin
5. para-aminosalicylic acid

Item Number: 12787   correct answer: 3  category: Antituberculars
18.   Ethambutol has become a primary treatment drug in the therapy of tuberculosis
because of its infrequent side effects.  The only significant toxic effect is:
1. bone marrow suppression
2. renal tubular damage
3. retrobulbar neuritis
4. hepatitis
5. Stevens-Johnson Syndrome

Item Number: 13119   correct answer: 3  category: Antituberculars
19.   Failure of first-line drugs in the initial treatment of apparent pulmonary
tuberculosis may have several causes including poor patient compliance and
atypical mycobacterial infections, the latter usually requiring use of second-
line drugs.  All of the following are first-line drugs EXCEPT:
1. streptomycin
2. rifampin
3. ethionamide
4. ethambutol
5. isoniazid